Caribbean economies, lifestyles, activities, practices and operational cycles are intricately linked to climate, making them vulnerable to its variations and/or changes. As examples, climate extremes impact agriculture, fisheries, health, tourism, water availability, recreation, and energy usage, among other things. There is however limited incorporation of climate information in the long term developmental plans and policies of the region. This is in part due to a knowledge deficit about climate change, it’s likely manifestation in the region and the possible impact on Caribbean societies. In this paper, a review of the growing bank of knowledge about Caribbean climate science; variability and change is undertaken. Insight is offered into the basic science of climate change, past trends and future projections for Caribbean climate, and the possible implications for the region. In the end a case is made for a greater response to the threats posed by climate change on the basis of the sufficiency of our current knowledge of Caribbean climate science. A general profile of what the response may look like is also offered.