The purpose of this study was to analyze the effects of self-efficacy on academic success of first-generation college sophomore students. The participants in the study consisted of college sophomores from 5 of the 23 California State University campuses. An online College Self-Efficacy Inventory was employed to measure participants’ self-efficacy levels. The study explored four areas: the relationship between self-efficacy scores and academic success as defined by GPA and persistence rates, the academic success and persistence rates between first-generation and second-and-beyond-generation college sophomore students, the effects of the demographic factors of gender and ethnicity on self-efficacy, and the relationship between institution size and self-efficacy. Findings show that self-efficacy beliefs affect GPA and persistence rates of sophomore students and second-generation college sophomores outperform their first-generation peers.